[HTML][HTML] Activation of HIV-1 coreceptor (CXCR4) mediates myelosuppression
X Sanchez, B Cousins-Hodges, T Aguilar… - Journal of Biological …, 1997 - ASBMB
Chemokines are cytokines that activate and induce the migration of leukocytes. Stroma-
derived factor-1 (SDF-1) is a novel chemokine that blocks the entry of T-tropic HIV-1
mediated by fusin/CXCR4/LESTR (leukocyte-derived seven-transmembrane domain
receptor). In this work we demonstrate that SDF-1 triggers increases in intracellular calcium
and inhibits the proliferation of myeloid progenitor cell line 32D. By contrast, SDF-1 neither
triggers a calcium response nor affects the proliferation of the myeloid progenitor cell line …
derived factor-1 (SDF-1) is a novel chemokine that blocks the entry of T-tropic HIV-1
mediated by fusin/CXCR4/LESTR (leukocyte-derived seven-transmembrane domain
receptor). In this work we demonstrate that SDF-1 triggers increases in intracellular calcium
and inhibits the proliferation of myeloid progenitor cell line 32D. By contrast, SDF-1 neither
triggers a calcium response nor affects the proliferation of the myeloid progenitor cell line …