[PDF][PDF] Evidence for a common mechanism of action for fatty acids and thiazolidinedione antidiabetic agents on gene expression in preadipose cells.
A Ibrahimi, L Teboul, D Gaillard, EZ Amri… - Molecular …, 1994 - researchgate.net
Molecular pharmacology, 1994•researchgate.net
In diabetic rodents, thiazolidinediones are able to improve insulin sensitivity of target tissues
and to reverse, at least partially, the diabetic state. The effects of these drugs on phenotypic
expres-sion in various tissues, including adipose tissue, have been reported. We report here
that a new thiazolidinedione compound, BRL 49653, exerts, in preadipose cells, potent
effects on the expression of genes encoding proteins involved in fatty acid metabolism.
These effects of BRL 49653 in Ob 1771 preadipose cells are similar, in terms of kinetics …
and to reverse, at least partially, the diabetic state. The effects of these drugs on phenotypic
expres-sion in various tissues, including adipose tissue, have been reported. We report here
that a new thiazolidinedione compound, BRL 49653, exerts, in preadipose cells, potent
effects on the expression of genes encoding proteins involved in fatty acid metabolism.
These effects of BRL 49653 in Ob 1771 preadipose cells are similar, in terms of kinetics …
Summary
In diabetic rodents, thiazolidinediones are able to improve insulin sensitivity of target tissues and to reverse, at least partially, the diabetic state. The effects of these drugs on phenotypic expres-sion in various tissues, including adipose tissue, have been reported. We report here that a new thiazolidinedione compound, BRL 49653, exerts, in preadipose cells, potent effects on the expression of genes encoding proteins involved in fatty acid metabolism. These effects of BRL 49653 in Ob 1771 preadipose cells are similar, in terms of kinetics, reversibility, specificity of genes affected, and requirement for protein synthesis, to those already described for natural or nonmetabolizable fatty acids.
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