Fructose 2, 6-bisphosphate and the control of glycolysis by growth factors, tumor promoters and oncogenes
L Hue, GG Rousseau - Advances in enzyme regulation, 1993 - Elsevier
Tumor and proliferating cells maintain a high glycolytic rate even under aerobic conditions.
The discovery of fructose 2, 6-biphosphate, a potent stimulator of glycolysis, has prompted a
re-investigation of this phenomenon. Rat hepatoma cells and fibroblasts stimulated by
mitogens or transformed by the Rous sarcoma virus carrying the v-src oncogene were used
as models. The results indicate that in established lines of hepatoma cells the biochemical
properties of the bifunctional enzyme, PFK-2/FBPase-2, involved in the synthesis and …
The discovery of fructose 2, 6-biphosphate, a potent stimulator of glycolysis, has prompted a
re-investigation of this phenomenon. Rat hepatoma cells and fibroblasts stimulated by
mitogens or transformed by the Rous sarcoma virus carrying the v-src oncogene were used
as models. The results indicate that in established lines of hepatoma cells the biochemical
properties of the bifunctional enzyme, PFK-2/FBPase-2, involved in the synthesis and …