The role of programmed cell death (apoptosis) in thymic involution following sepsis
RA Barke, S Roy, RB Chapin… - Archives of …, 1994 - jamanetwork.com
Objective: To test the hypothesis that thymic involution following peritoneal sepsis is
secondary to thymocyte programmed cell death. Design: We investigated the temporal
response of thymic weight and thymic DNA fragmentation following peritoneal sepsis
induced by cecal ligation and puncture in a rat model. We investigated the possible role of
decreased interleukin (IL)-2 synthesis in the induction of apoptosis using rat thymocytes in
primary culture. Finally, we studied IL-2 gene expression and IL-2 protein synthesis in …
secondary to thymocyte programmed cell death. Design: We investigated the temporal
response of thymic weight and thymic DNA fragmentation following peritoneal sepsis
induced by cecal ligation and puncture in a rat model. We investigated the possible role of
decreased interleukin (IL)-2 synthesis in the induction of apoptosis using rat thymocytes in
primary culture. Finally, we studied IL-2 gene expression and IL-2 protein synthesis in …