Anaphylatoxin formation in sepsis
A Bengtson, M Heideman - Archives of Surgery, 1988 - jamanetwork.com
• Complement activation and anaphylatoxin formation were studied in 27 septic patients.
The patients were treated with antibiotics and high-dose corticosteroids. Blood samples
were drawn on admission and every week thereafter. Plasma levels of complement
components C1INH, C3, C4, and C5 were low before the start of treatment but were above
normal one week later in both successfully and unsuccessfully treated patients. In contrast,
plasma levels of anaphylatoxins C3a/C3a desArg and C5a/C5a desArg were elevated on …
The patients were treated with antibiotics and high-dose corticosteroids. Blood samples
were drawn on admission and every week thereafter. Plasma levels of complement
components C1INH, C3, C4, and C5 were low before the start of treatment but were above
normal one week later in both successfully and unsuccessfully treated patients. In contrast,
plasma levels of anaphylatoxins C3a/C3a desArg and C5a/C5a desArg were elevated on …