[HTML][HTML] Plasma and fibroblasts of Tangier disease patients are disturbed in transferring phospholipids onto apolipoprotein AI
A von Eckardstein, A Chirazi, S Schuler-Lüttmann… - Journal of lipid …, 1998 - ASBMB
Plasmas of patients with Tangier disease (TD) lack lipid-rich α-HDL which, in normal
plasma, constitutes the majority of high density lipoprotein (HDL). Residual amounts of
apolipoprotein (apo) AI in TD plasma occur as lipid-poor or even lipid-free preβ-HDL. By
contrast to normal plasma, TD plasma does not convert preβ-HDL into α-HDL. Moreover,
fibroblasts of TD patients were found to be defective in secreting cholesterol or
phospholipids in the presence of lipid-free apoA-I. We have therefore hypothesized that both …
plasma, constitutes the majority of high density lipoprotein (HDL). Residual amounts of
apolipoprotein (apo) AI in TD plasma occur as lipid-poor or even lipid-free preβ-HDL. By
contrast to normal plasma, TD plasma does not convert preβ-HDL into α-HDL. Moreover,
fibroblasts of TD patients were found to be defective in secreting cholesterol or
phospholipids in the presence of lipid-free apoA-I. We have therefore hypothesized that both …