ApoA-I knockout mice: characterization of HDL metabolism in homozygotes and identification of a post-RNA mechanism of apoA-I up-regulation in heterozygotes
AS Plump, N Azrolan, H Odaka, L Wu, X Jiang… - Journal of lipid …, 1997 - ASBMB
The major high density lipoprotein (HDL) apolipoprotein, apoA-I, was knocked out by gene
targeting in ES cells to provide a model for the study of HDL metabolism and its relationship
to plasma and tissue cholesterol metabolism. HDL and non-HDL cholesterol (HDL-C) were
reduced in apoA-I-deficient mice. Feeding a high fat-high cholesterol diet raised HDL-C
minimally in apoA-I knockout compared to the large increase seen in control mice,
suggesting an interaction between diet and apoA-I genotype. In apoA-I-deficient mice, HDL …
targeting in ES cells to provide a model for the study of HDL metabolism and its relationship
to plasma and tissue cholesterol metabolism. HDL and non-HDL cholesterol (HDL-C) were
reduced in apoA-I-deficient mice. Feeding a high fat-high cholesterol diet raised HDL-C
minimally in apoA-I knockout compared to the large increase seen in control mice,
suggesting an interaction between diet and apoA-I genotype. In apoA-I-deficient mice, HDL …