[HTML][HTML] Interaction between G Proteins and Tyrosine Kinases upon T Cell Receptor· CD3-mediated Signaling (∗)
J Stanners, PS Kabouridis, KL McGuire… - Journal of Biological …, 1995 - ASBMB
Engagement of the T cell receptor (TCR)· CD3 complex results in the induction of multiple
intracellular events, with protein tyrosine kinases playing a pivotal role in their initiation.
Biochemical studies also exist suggesting the involvement of heterotrimeric GTP-binding
proteins (G proteins); however, the functional consequence of this participation in TCR· CD3-
mediated signaling is unresolved. Here, we report TCR· CD3-mediated guanine nucleotide
exchange among the 42-kDa G protein α subunits of the Gαq/11 family, their physical …
intracellular events, with protein tyrosine kinases playing a pivotal role in their initiation.
Biochemical studies also exist suggesting the involvement of heterotrimeric GTP-binding
proteins (G proteins); however, the functional consequence of this participation in TCR· CD3-
mediated signaling is unresolved. Here, we report TCR· CD3-mediated guanine nucleotide
exchange among the 42-kDa G protein α subunits of the Gαq/11 family, their physical …