Mouse germline transcript of TCR α joining region and temporal expression in ontogeny
T Shimizu, S Takeshita, M Muto, E Kubo… - International …, 1993 - academic.oup.com
T Shimizu, S Takeshita, M Muto, E Kubo, T Sado, H Yamagishi
International immunology, 1993•academic.oup.comThe genetic element 'T early α'(TEA) in humans is located immediately 5′ to the most
upstream joining segment (ψ J α) of the TCR α chain locus. The TEA transcript is present
early in thymocyte ontogeny and the TEA-associated deletion of the TCR δ locus (δRec/ψ J
α rearrangement) precedes V α/J α rearrangement. We detected a 1.8 kb transcript
homologous to human TEA that is spliced to C α in mouse thymic lymphomas showing
concomitant rearrangement and expression of TCR γ, δ, β, and α. The TEA expression was …
upstream joining segment (ψ J α) of the TCR α chain locus. The TEA transcript is present
early in thymocyte ontogeny and the TEA-associated deletion of the TCR δ locus (δRec/ψ J
α rearrangement) precedes V α/J α rearrangement. We detected a 1.8 kb transcript
homologous to human TEA that is spliced to C α in mouse thymic lymphomas showing
concomitant rearrangement and expression of TCR γ, δ, β, and α. The TEA expression was …
Abstract
The genetic element ‘T early α’ (TEA) in humans is located immediately 5′ to the most upstream joining segment (ψJα) of the TCR α chain locus. The TEA transcript is present early in thymocyte ontogeny and the TEA-associated deletion of the TCR δ locus (δRec/ψJαrearrangement) precedes Vα/Jα rearrangement. We detected a 1.8 kb transcript homologous to human TEA that is spliced to Cα in mouse thymic lymphomas showing concomitant rearrangement and expression of TCR γ, δ, β, and α. The TEA expression was highest in day 17 fetal thymocytes and declined thereafter. This expression parallels the TCR α gene expression which is preceded by TCR γ expression, and followed by the expression of TCR β and α genes.
Oxford University Press