Substantial inhibition of neo-intimal response to balloon injury in the rat carotid artery using a combination of antibodies to platelet-derived growth factor-BB and basic …
C Rutherford, W Martin, M Salame, M Carrier… - Atherosclerosis, 1997 - Elsevier
Thirty percent of patients undergoing percutaneous transluminal coronary angioplasty
develop recurrent disease within a year. This is usually due to the rapid accumulation of
intimal smooth muscle cells and extracellular matrix, which causes luminal narrowing, and is
probably orchestrated by several mitogenic and chemotactic factors, of which platelet-
derived growth factor (PDGF) and basic fibroblast growth factor (bFGF) appear to be
particularly important. We have investigated the effects of administering a combination of …
develop recurrent disease within a year. This is usually due to the rapid accumulation of
intimal smooth muscle cells and extracellular matrix, which causes luminal narrowing, and is
probably orchestrated by several mitogenic and chemotactic factors, of which platelet-
derived growth factor (PDGF) and basic fibroblast growth factor (bFGF) appear to be
particularly important. We have investigated the effects of administering a combination of …