[HTML][HTML] Transcription factors Sp1 and Sp3 alter vascular endothelial growth factor receptor expression through a novel recognition sequence
Kinase domain receptor (KDR) is a high affinity, endothelial cell-specific,
autophosphorylating tyrosine kinase receptor for vascular endothelial growth factor. This
transcriptionally regulated receptor is a critical mediator of endothelial cell (EC) growth and
vascular development. In this study, we identify a DNA element modulating KDR promoter
activity and evaluate the nuclear binding proteins accounting for a portion of the cell-type
specificity of the region. KDR promoter luciferase activity was retained within− 85/+ 296 and …
autophosphorylating tyrosine kinase receptor for vascular endothelial growth factor. This
transcriptionally regulated receptor is a critical mediator of endothelial cell (EC) growth and
vascular development. In this study, we identify a DNA element modulating KDR promoter
activity and evaluate the nuclear binding proteins accounting for a portion of the cell-type
specificity of the region. KDR promoter luciferase activity was retained within− 85/+ 296 and …