Characterization of anti-heart antibodies in mice after infection with coxsackie B3 virus
N Latif, H Zhang, LC Archard, MH Yacoub, MJ Dunn - Clinical Immunology, 1999 - Elsevier
Coxsackie virus B3 (CVB3) infection results in a marked inflammatory response and the
production of autoantibodies to cardiac antigens, with cardiac myosin heavy chain
documented to be the most immunogenic antigen. The present study investigated the
temporal appearance of anti-heart antibodies in mice after mock infection or infection with an
attenuated variant of CVB3 or wildtpye CVB3 by SDS–PAGE and Western blotting. Further
characterization of the autoantigens was carried out using 2D electrophoresis followed by …
production of autoantibodies to cardiac antigens, with cardiac myosin heavy chain
documented to be the most immunogenic antigen. The present study investigated the
temporal appearance of anti-heart antibodies in mice after mock infection or infection with an
attenuated variant of CVB3 or wildtpye CVB3 by SDS–PAGE and Western blotting. Further
characterization of the autoantigens was carried out using 2D electrophoresis followed by …