Apolipoprotein J (apoJ) has been shown to be the predominant amyloid β-peptide (Aβ)-
binding protein in cerebrospinal fluid. We have previously demonstrated that the endocytic
receptor low density lipoprotein receptor-related protein-2/megalin (LRP-2), which is
expressed by choroid plexus epithelium and ependymal cells lining the brain ventricles and
neural tube, binds and mediates cellular uptake of apoJ (Kounnas, MZ, Loukinova, EB,
Stefansson, S., Harmony, JA, Brewer, B., Strickland, DK, and Argraves, WS (1995) J. Biol …