Transcription factor decoy for nuclear factor-κB inhibits tumor necrosis factor-α-induced expression of interleukin-6 and intracellular adhesion molecule-1 in …

N Tomita, R Morishita, S Tomita… - Journal of …, 1998 - journals.lww.com
N Tomita, R Morishita, S Tomita, K Yamamoto, M Aoki, H Matsushita, S Hayashi, J Higaki…
Journal of hypertension, 1998journals.lww.com
Background Several cytokines and adhesion molecules released from endothelium play an
important role in inflammation, immune responses, and probably atherogenesis. Objective
To determine whether the transcription factor nuclear factor-κB mediated expression of these
genes involved in the inflammatory response of endothelial cells to tumor necrosis factor-α,
by using transcription factor decoy oligodeoxynucleotides.
Abstract
Background
Several cytokines and adhesion molecules released from endothelium play an important role in inflammation, immune responses, and probably atherogenesis.
Objective
To determine whether the transcription factor nuclear factor-κB mediated expression of these genes involved in the inflammatory response of endothelial cells to tumor necrosis factor-α, by using transcription factor decoy oligodeoxynucleotides.
Lippincott Williams & Wilkins