[HTML][HTML] Transcription of the sodium/myo-inositol cotransporter gene is regulated by multiple tonicity-responsive enhancers spread over 50 kilobase pairs in the 5 …
JS Rim, MG Atta, SC Dahl, GT Berry, JS Handler… - Journal of Biological …, 1998 - ASBMB
The sodium/myo-inositol cotransporter is a plasma membrane protein responsible for
concentrative cellular accumulation of myo-inositol in a variety of tissues. When cells in
kidney and brain are exposed to a hyperosmolar salt condition (hypertonicity) due to the
operation of urinary concentration mechanism and pathological conditions, respectively,
they survive the stress of hypertonicity by raising the cellular concentration ofmyo-inositol.
Transcription of the sodium/myo-inositol cotransporter gene is markedly stimulated in …
concentrative cellular accumulation of myo-inositol in a variety of tissues. When cells in
kidney and brain are exposed to a hyperosmolar salt condition (hypertonicity) due to the
operation of urinary concentration mechanism and pathological conditions, respectively,
they survive the stress of hypertonicity by raising the cellular concentration ofmyo-inositol.
Transcription of the sodium/myo-inositol cotransporter gene is markedly stimulated in …