[HTML][HTML] Regulation of cyclooxygenase-2 by interferon γ and transforming growth factor α in normal human epidermal keratinocytes and squamous carcinoma cells …
H Matsuura, M Sakaue, K Subbaramaiah… - Journal of Biological …, 1999 - ASBMB
Treatment of normal human epidermal keratinocytes (NHEK) with interferon-γ (IFN-γ) causes
a 9-fold increase in the level of cyclooxygenase-2 (COX-2) mRNA expression. Nuclear run-
off assays indicate that this induction is at least partly due to increased transcription.
Activation of the epidermal growth factor receptor (EGFR) signaling pathway due to the
enhanced transforming growth factor α (TGFα) expression plays an important role in the
induction of COX-2 by IFN-γ. This is supported by the ability of TGFα to rapidly induce COX-2 …
a 9-fold increase in the level of cyclooxygenase-2 (COX-2) mRNA expression. Nuclear run-
off assays indicate that this induction is at least partly due to increased transcription.
Activation of the epidermal growth factor receptor (EGFR) signaling pathway due to the
enhanced transforming growth factor α (TGFα) expression plays an important role in the
induction of COX-2 by IFN-γ. This is supported by the ability of TGFα to rapidly induce COX-2 …