Pax-3 contains domains for transcription activation and transcription inhibition.

G Chalepakis, FS Jones… - Proceedings of the …, 1994 - National Acad Sciences
G Chalepakis, FS Jones, GM Edelman, P Gruss
Proceedings of the National Academy of Sciences, 1994National Acad Sciences
Pax-3 is a member of the Pax family of transcription factors involved in transcriptional control
events during embryonic development. Here we report a functional dissection of the Pax-3
protein and describe the protein domains which are responsible for different activities. A
transcription inhibition activity is located in the first 90 N-terminal amino acids and includes
part of the paired domain. Furthermore, the C terminus of Pax-3 is able to confer
transcriptional activation of basal promoters. Pax-3 can utilize both transcription modulating …
Pax-3 is a member of the Pax family of transcription factors involved in transcriptional control events during embryonic development. Here we report a functional dissection of the Pax-3 protein and describe the protein domains which are responsible for different activities. A transcription inhibition activity is located in the first 90 N-terminal amino acids and includes part of the paired domain. Furthermore, the C terminus of Pax-3 is able to confer transcriptional activation of basal promoters. Pax-3 can utilize both transcription modulating functions and activates transcription over a narrow range of protein concentration in the presence of promoter elements containing functional binding sites.
National Acad Sciences