Analysis of the developmental effects of a lethal mutation in the house mouse.
R Auerbach - 1954 - cabidigitallibrary.org
1954•cabidigitallibrary.org
The effects of the dominant mutation" Splotch" in homozygous condition were studied. Homo-
zygous Splotch embryos can first be recognised 91/2 days after fertilization and die at the
beginning of the 13th day of development. The causal relationships involved in the
production of the abnormalities observed are discussed. It is concluded that the Splotch
syndrome is based on a disturbance of the region of the developing embryo which includes
the neural crest and the dorsal part of the neural tube.-Part of author's summary.
zygous Splotch embryos can first be recognised 91/2 days after fertilization and die at the
beginning of the 13th day of development. The causal relationships involved in the
production of the abnormalities observed are discussed. It is concluded that the Splotch
syndrome is based on a disturbance of the region of the developing embryo which includes
the neural crest and the dorsal part of the neural tube.-Part of author's summary.
Abstract
The effects of the dominant mutation " Splotch " in homozygous condition were studied. Homo-zygous Splotch embryos can first be recognised 91/2 days after fertilization and die at the beginning of the 13th day of development. The causal relationships involved in the production of the abnormalities observed are discussed. It is concluded that the Splotch syndrome is based on a disturbance of the region of the developing embryo which includes the neural crest and the dorsal part of the neural tube.-Part of author's summary.
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