Prospects for new vaccines against tuberculosis
IM Orme - Trends in microbiology, 1995 - cell.com
IM Orme
Trends in microbiology, 1995•cell.comThe spectacular failure of the existing bacille Calmette-Guérin (BCG) vaccine in recent
tuberculosis-control trials has prompted a search for potential replacements. Imaginative
approaches currently under development include the modulation of BCG by the production
of auxotrophic mutants or cytokine-secreting recombinants, and the development of subunit
vaccines based on the major proteins of Mycobacterium tuberculosis.
tuberculosis-control trials has prompted a search for potential replacements. Imaginative
approaches currently under development include the modulation of BCG by the production
of auxotrophic mutants or cytokine-secreting recombinants, and the development of subunit
vaccines based on the major proteins of Mycobacterium tuberculosis.
Abstract
The spectacular failure of the existing bacille Calmette-Guérin (BCG) vaccine in recent tuberculosis-control trials has prompted a search for potential replacements. Imaginative approaches currently under development include the modulation of BCG by the production of auxotrophic mutants or cytokine-secreting recombinants, and the development of subunit vaccines based on the major proteins of Mycobacterium tuberculosis.
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