T cell activation determined by T cell receptor number and tunable thresholds
A Viola, A Lanzavecchia - Science, 1996 - science.org
Science, 1996•science.org
The requirements for T cell activation have been reported to vary widely depending on the
state of the T cell, the type of antigen-presenting cell, and the nature of the T cell receptor
(TCR) ligand. A unitary requirement for T cell responses was revealed by measurement of
the number of triggered TCRs. Irrespective of the nature of the triggering ligand, T cells"
counted" the number of triggered TCRs and responded when a threshold of∼ 8000 TCRs
was reached. The capacity to reach the activation threshold was severely compromised by a …
state of the T cell, the type of antigen-presenting cell, and the nature of the T cell receptor
(TCR) ligand. A unitary requirement for T cell responses was revealed by measurement of
the number of triggered TCRs. Irrespective of the nature of the triggering ligand, T cells"
counted" the number of triggered TCRs and responded when a threshold of∼ 8000 TCRs
was reached. The capacity to reach the activation threshold was severely compromised by a …
The requirements for T cell activation have been reported to vary widely depending on the state of the T cell, the type of antigen-presenting cell, and the nature of the T cell receptor (TCR) ligand. A unitary requirement for T cell responses was revealed by measurement of the number of triggered TCRs. Irrespective of the nature of the triggering ligand, T cells "counted" the number of triggered TCRs and responded when a threshold of ∼8000 TCRs was reached. The capacity to reach the activation threshold was severely compromised by a reduction in the number of TCRs. Costimulatory signals lowered the activation threshold to ∼1500 TCRs, thus making T cells more sensitive to antigenic stimulation.
AAAS