In vitro evaluation of dose-effects of ethanol on human osteoblastic cells
P Chavassieux, CM Serre, P Vergnaud, PD Delmas… - Bone and mineral, 1993 - Elsevier
Chronic alcoholism represents a high risk for fractures and osteopenia. Previous
histomorphometric studies reported a decreased bone formation, but it has never been
established whether ethanol has a direct toxic effect on osteoblasts. This present in vitro
study was performed on human osteoblast cells derived from bone expiants after
collagenase digestion. The direct effect of ethanol was determined after 4 days of exposure
to various doses, ranging from 0.01 to 5 g/1 on the alkaline phosphatase (AP) activity …
histomorphometric studies reported a decreased bone formation, but it has never been
established whether ethanol has a direct toxic effect on osteoblasts. This present in vitro
study was performed on human osteoblast cells derived from bone expiants after
collagenase digestion. The direct effect of ethanol was determined after 4 days of exposure
to various doses, ranging from 0.01 to 5 g/1 on the alkaline phosphatase (AP) activity …