Hypogonadism precedes liver feminization in chronic alcohol-fed male rats
SD Tadic, MS Elm, VM Subbotin, PK Eagon - Hepatology, 2000 - journals.lww.com
Men who chronically abuse alcohol may display a spectrum of endocrine abnormalities
including hypogonadism and feminization, with elevated serum estradiol and low serum
testosterone. We examined factors that may result in disruption of hepatic sex hormone
homeostasis in alcohol-fed male rats and possible consequences of such changes. Rats
were fed alcohol-containing or isocaloric diets for 30, 60, and 90 days. In alcohol-fed rats,
serum testosterone levels and hepatic activity of 2 androgen-dependent estrogen …
including hypogonadism and feminization, with elevated serum estradiol and low serum
testosterone. We examined factors that may result in disruption of hepatic sex hormone
homeostasis in alcohol-fed male rats and possible consequences of such changes. Rats
were fed alcohol-containing or isocaloric diets for 30, 60, and 90 days. In alcohol-fed rats,
serum testosterone levels and hepatic activity of 2 androgen-dependent estrogen …