Residual HIV-1 RNA in blood plasma of patients taking suppressive highly active antiretroviral therapy

G Dornadula, H Zhang, B VanUitert, J Stern… - Jama, 1999 - jamanetwork.com
ContextDespite suppressive treatment with highly active antiretroviral therapy (HAART),
replication-competent virus can still be isolated from peripheral blood mononuclear cells
and genital cells of many individuals receiving suppressive HAART. ObjectiveTo determine
whether free virion RNA can be detected in the blood plasma and/or genital tract fluids from
patients receiving suppressive HAART. DesignProspective cohort study conducted from
November 1998 to May 1999. SettingAcademic medical center. PatientsHuman …