Effects of vascular permeability factor on the permeability of cultured endothelial cells from brain capillaries
L Zhao, MM Zhang, K Ng - Journal of cardiovascular …, 1998 - journals.lww.com
L Zhao, MM Zhang, K Ng
Journal of cardiovascular pharmacology, 1998•journals.lww.comThe effects of vascular permeability factor (VPF) on the blood-brain barrier (BBB)
permeability were studied in cultured capillary endothelial cells from bovine brain. When
VPF was added to the abluminal or brain side of the BBB, a rapid increase in the BBB
permeability was observed. This increase in the BBB permeability is dependent on the
concentration of the VPF used and is reversible on removal of the VPF. Contrarily, when VPF
was added to the luminal or blood side of the BBB, no increase in the BBB permeability was …
permeability were studied in cultured capillary endothelial cells from bovine brain. When
VPF was added to the abluminal or brain side of the BBB, a rapid increase in the BBB
permeability was observed. This increase in the BBB permeability is dependent on the
concentration of the VPF used and is reversible on removal of the VPF. Contrarily, when VPF
was added to the luminal or blood side of the BBB, no increase in the BBB permeability was …
Abstract
The effects of vascular permeability factor (VPF) on the blood-brain barrier (BBB) permeability were studied in cultured capillary endothelial cells from bovine brain. When VPF was added to the abluminal or brain side of the BBB, a rapid increase in the BBB permeability was observed. This increase in the BBB permeability is dependent on the concentration of the VPF used and is reversible on removal of the VPF. Contrarily, when VPF was added to the luminal or blood side of the BBB, no increase in the BBB permeability was observed. These results suggest that the receptors for VPF are located on the abluminal side of the BBB.
Lippincott Williams & Wilkins