Association of activated cytolytic lung lymphocytes with response to prednisone therapy in patients with idiopathic pulmonary fibrosis
JP Karpel, AJ Norin - Chest, 1989 - Elsevier
Previous studies have suggested that immunologic mechanisms may contribute to
pathogeneic reactions in certain interstitial lung diseases. Cytolytic lymphocytes are major
effector cells of the immune response that have not been extensively studied in these
disorders. To investigate the role of activated cytolytic lymphocytes in IPF, we studied B-cell
and monocyte/macrophage-depleted lymphocyte preparations isolated from BAL fluid and
peripheral blood of patients with this disease (n= 10) and used a lectin-dependent …
pathogeneic reactions in certain interstitial lung diseases. Cytolytic lymphocytes are major
effector cells of the immune response that have not been extensively studied in these
disorders. To investigate the role of activated cytolytic lymphocytes in IPF, we studied B-cell
and monocyte/macrophage-depleted lymphocyte preparations isolated from BAL fluid and
peripheral blood of patients with this disease (n= 10) and used a lectin-dependent …