Ischemic tolerance in the brain
J Chen, R Simon - Neurology, 1997 - AAN Enterprises
J Chen, R Simon
Neurology, 1997•AAN EnterprisesBrief episodes of brain ischemia define a patient population at increased risk for stroke.
These brief events (TIAs) warrant urgent evaluation and treatment. It is therefore
counterintuitive that transient ischemia might induce tolerance and protect the brain from
subsequent ischemia. However, accumulating data from studies on both myocardium and
brain support such a concept. An understanding of the mechanisms involved in ischemic
tolerance may define novel therapeutic strategies for brain protection.
These brief events (TIAs) warrant urgent evaluation and treatment. It is therefore
counterintuitive that transient ischemia might induce tolerance and protect the brain from
subsequent ischemia. However, accumulating data from studies on both myocardium and
brain support such a concept. An understanding of the mechanisms involved in ischemic
tolerance may define novel therapeutic strategies for brain protection.
Brief episodes of brain ischemia define a patient population at increased risk for stroke. These brief events (TIAs) warrant urgent evaluation and treatment. It is therefore counterintuitive that transient ischemia might induce tolerance and protect the brain from subsequent ischemia. However, accumulating data from studies on both myocardium and brain support such a concept. An understanding of the mechanisms involved in ischemic tolerance may define novel therapeutic strategies for brain protection.
American Academy of Neurology