[HTML][HTML] Placental transforming growth factor-β is a downstream mediator of the growth arrest and apoptotic response of tumor cells to DNA damage and p53 …
PX Li, J Wong, A Ayed, D Ngo, AM Brade… - Journal of Biological …, 2000 - ASBMB
The p53 tumor suppressor gene and members of the transforming growth factor-β (TGF-β)
superfamily play central roles in signaling cell cycle arrest and apoptosis (programmed cell
death) in normal development and differentiation, as well as in carcinogenesis. Here we
describe a distantly related member of the TGF-β superfamily, designated placental TGF-β
(PTGF-β), that is up-regulated in response to both p53-dependent and-independent
apoptotic signaling events arising from DNA damage in human breast cancer cells. PTGF-β …
superfamily play central roles in signaling cell cycle arrest and apoptosis (programmed cell
death) in normal development and differentiation, as well as in carcinogenesis. Here we
describe a distantly related member of the TGF-β superfamily, designated placental TGF-β
(PTGF-β), that is up-regulated in response to both p53-dependent and-independent
apoptotic signaling events arising from DNA damage in human breast cancer cells. PTGF-β …