[HTML][HTML] Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF-κB
T Shalom-Barak, J Quach, M Lotz - Journal of Biological Chemistry, 1998 - ASBMB
This study examines intracellular signaling events associated with the activation of
chondrocytes by the cytokine interleukin-17 (IL-17). Stimulation of normal human articular
chondrocytes with IL-17 induced nitric oxide (NO) production, concomitant with an increase
in transcripts and de novotranslation products of the inducible nitric oxide synthase (iNOS)
and cyclooxygenase-2 (COX-2) genes. Several other genes associated with inflammation
and cartilage degradation, such as IL-1β, IL-6, and stromelysin, were also up-regulated in IL …
chondrocytes by the cytokine interleukin-17 (IL-17). Stimulation of normal human articular
chondrocytes with IL-17 induced nitric oxide (NO) production, concomitant with an increase
in transcripts and de novotranslation products of the inducible nitric oxide synthase (iNOS)
and cyclooxygenase-2 (COX-2) genes. Several other genes associated with inflammation
and cartilage degradation, such as IL-1β, IL-6, and stromelysin, were also up-regulated in IL …