[HTML][HTML] Cell shrinkage triggers the activation of mitogen-activated protein kinases by hypertonicity in the rat kidney medullary thick ascending limb of the Henle's loop …
F Roger, PY Martin, M Rousselot, H Favre… - Journal of Biological …, 1999 - ASBMB
The kidney medulla is exposed to very high interstitial osmolarity leading to the activation of
mitogen-activated protein kinases (MAPK). However, the respective roles of increased
intracellular osmolality and of cell shrinkage in MAPK activation are not known. Similarly, the
participation of MAPK in the regulatory volume increase (RVI) following cell shrinkage
remains to be investigated. In the rat medullary thick ascending limb of Henle (MTAL),
extracellular hypertonicity produced by addition of NaCl or sucrose increased the …
mitogen-activated protein kinases (MAPK). However, the respective roles of increased
intracellular osmolality and of cell shrinkage in MAPK activation are not known. Similarly, the
participation of MAPK in the regulatory volume increase (RVI) following cell shrinkage
remains to be investigated. In the rat medullary thick ascending limb of Henle (MTAL),
extracellular hypertonicity produced by addition of NaCl or sucrose increased the …