[HTML][HTML] Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase
JL Kummer, PK Rao, KA Heidenreich - Journal of Biological Chemistry, 1997 - ASBMB
p38 is a member of the mitogen-activated protein (MAP) kinase superfamily activated by
stress signals and implicated in cellular processes involving inflammation and apoptosis.
Unlike the extracellular signal-regulated kinases (p42 and p44 MAP kinases), which are
stimulated by insulin in many cell types, p38 activity is inhibited by insulin in postmitotic fetal
neurons for which insulin is a potent survival factor (Heidenreich, KA, and Kummer, JL
(1996) J. Biol. Chem. 271, 9891–9894). These data suggested that insulin's effects on …
stress signals and implicated in cellular processes involving inflammation and apoptosis.
Unlike the extracellular signal-regulated kinases (p42 and p44 MAP kinases), which are
stimulated by insulin in many cell types, p38 activity is inhibited by insulin in postmitotic fetal
neurons for which insulin is a potent survival factor (Heidenreich, KA, and Kummer, JL
(1996) J. Biol. Chem. 271, 9891–9894). These data suggested that insulin's effects on …