Prevention of chronic relapsing experimental autoimmune encephalomyelitis by soluble tumor necrosis factor receptor I
K Selmaj, W Papierz, A Glabinski, T Kohno - Journal of neuroimmunology, 1995 - Elsevier
We have evaluated the effect of the type I (p-55, type β) soluble tumor necrosis factor
receptor (sTNFrI) in an animal model of multiple sclerosis. Experimental autoimmune
encephalomyelitis (EAE) was induced in SJL/J mice by adoptive transfer of T lymphocytes
sensitized to myelin basic protein (MBP). sTNFrI completely blocked both clinical signs of
disease and pathological changes that included CNS demyelination and inflammatory cell
infiltration. Effective inhibition of disease expression was obtained using several different …
receptor (sTNFrI) in an animal model of multiple sclerosis. Experimental autoimmune
encephalomyelitis (EAE) was induced in SJL/J mice by adoptive transfer of T lymphocytes
sensitized to myelin basic protein (MBP). sTNFrI completely blocked both clinical signs of
disease and pathological changes that included CNS demyelination and inflammatory cell
infiltration. Effective inhibition of disease expression was obtained using several different …