[HTML][HTML] Proteasome inhibition leads to a heat-shock response, induction of endoplasmic reticulum chaperones, and thermotolerance
The accumulation of misfolded proteins in the cytosol leads to increased expression of heat-
shock proteins, while accumulation of such proteins in the endoplasmic reticulum (ER)
stimulates the expression of many ER resident proteins, most of which function as molecular
chaperones. Recently, inhibitors of the proteasome have been identified that can block the
rapid degradation of abnormal cytosolic and ER-associated proteins. We therefore tested
whether these agents, y causing the accumulation of abnormal proteins, might stimulate the …
shock proteins, while accumulation of such proteins in the endoplasmic reticulum (ER)
stimulates the expression of many ER resident proteins, most of which function as molecular
chaperones. Recently, inhibitors of the proteasome have been identified that can block the
rapid degradation of abnormal cytosolic and ER-associated proteins. We therefore tested
whether these agents, y causing the accumulation of abnormal proteins, might stimulate the …