[HTML][HTML] Protein-tyrosine phosphatase SHP2 is positively linked to proteinase-activated receptor 2-mediated mitogenic pathway

Z Yu, S Ahmad, JL Schwartz, D Banville… - Journal of Biological …, 1997 - ASBMB
Proteinase-activated receptor-2 (PAR2), a new member of family of the G protein-coupled
receptors, is activated by proteolytic cleavage of its extracellular amino terminus, a
mechanism similar to that used by the thrombin receptor. It has been suggested that PAR2
has a potential role in the late phases of the acute inflammatory response and in tissue
repair and/or skin-related disorders. Here we demonstrate that the agonist peptide (SLIGRL)
stimulated c-fos-mediated mitogenic activation and tyrosine phosphorylation of cellular …