Thrombin regulates PDGF expression in bovine glomerular endothelial cells.
G Grandaliano, GG Choudhury, E Poptic… - Journal of the …, 1998 - journals.lww.com
The proteolytic enzyme thrombin is produced during activation of the coagulation pathway.
Intraglomerular fibrin deposition and thrombosis are common pathologic features of several
glomerular diseases, including transplant rejection. The effect of thrombin on platelet-
derived growth factor (PDGF) production and DNA synthesis in well characterized bovine
glomerular endothelial cells (G/endo) was studied. DNA synthesis was measured as the
amount of [3H] thymidine incorporated into acid-insoluble material. PDGF released in the …
Intraglomerular fibrin deposition and thrombosis are common pathologic features of several
glomerular diseases, including transplant rejection. The effect of thrombin on platelet-
derived growth factor (PDGF) production and DNA synthesis in well characterized bovine
glomerular endothelial cells (G/endo) was studied. DNA synthesis was measured as the
amount of [3H] thymidine incorporated into acid-insoluble material. PDGF released in the …