TNF-α and insulin resistance: summary and future prospects
P Peraldi, B Spiegelman - Molecular and cellular biochemistry, 1998 - Springer
Molecular and cellular biochemistry, 1998•Springer
While the causes of obesity remain elusive, the relationship between obesity and insulin
resistance is a well-established fact [1]. Insulin resistance is defined as a smaller than
normal response to a certain dose of insulin, and contributes to several pathological
problems of obese patients such as hyperlipidemia, arteriosclerosis and hypertension.
Several pieces of evidence indicate that the cytokine tumor necrosis factor a (TNF-α) is an
important player in the state of insulin resistance observed during obesity. In this review we …
resistance is a well-established fact [1]. Insulin resistance is defined as a smaller than
normal response to a certain dose of insulin, and contributes to several pathological
problems of obese patients such as hyperlipidemia, arteriosclerosis and hypertension.
Several pieces of evidence indicate that the cytokine tumor necrosis factor a (TNF-α) is an
important player in the state of insulin resistance observed during obesity. In this review we …
Abstract
While the causes of obesity remain elusive, the relationship between obesity and insulin resistance is a well-established fact [1]. Insulin resistance is defined as a smaller than normal response to a certain dose of insulin, and contributes to several pathological problems of obese patients such as hyperlipidemia, arteriosclerosis and hypertension. Several pieces of evidence indicate that the cytokine tumor necrosis factor a (TNF-α) is an important player in the state of insulin resistance observed during obesity. In this review we will try to summarize what is known about the function of TNF-a in insulin resistance during obesity and how TNF-α interferes with insulin signaling.
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