[HTML][HTML] Role of insulin receptor substrate-1 and pp60 in the regulation of insulin-induced glucose transport and GLUT4 translocation in primary adipocytes
Y Kaburagi, S Satoh, H Tamemoto… - Journal of Biological …, 1997 - ASBMB
In muscle and fat, glucose transport occurs through the translocation of GLUT4 from an
intracellular pool to the cell surface. Phosphatidylinositol (PI) 3-kinase has been shown to be
required in this process. Insulin is thought to activate this enzyme by stimulating its
association with tyrosine-phosphorylated proteins such as insulin receptor substrate (IRS)-1,
IRS-2, Grb2-associated binder-1, and pp60. To study the role of these endogenous
substrates in glucose transport, we analyzed adipocytes from IRS-1 null mice that we …
intracellular pool to the cell surface. Phosphatidylinositol (PI) 3-kinase has been shown to be
required in this process. Insulin is thought to activate this enzyme by stimulating its
association with tyrosine-phosphorylated proteins such as insulin receptor substrate (IRS)-1,
IRS-2, Grb2-associated binder-1, and pp60. To study the role of these endogenous
substrates in glucose transport, we analyzed adipocytes from IRS-1 null mice that we …