[HTML][HTML] Muscle-specific overexpression of FAT/CD36 enhances fatty acid oxidation by contracting muscle, reduces plasma triglycerides and fatty acids, and increases …
A Ibrahimi, A Bonen, WD Blinn, T Hajri, X Li… - Journal of Biological …, 1999 - ASBMB
Increasing evidence has implicated the membrane protein CD36 (FAT) in binding and
transport of long chain fatty acids (FA). To determine the physiological role of CD36, we
examined effects of its overexpression in muscle, a tissue that depends on FA for its energy
needs and is responsible for clearing a major fraction of circulating FA. Mice with CD36
overexpression in muscle were generated using the promoter of the muscle creatine kinase
gene (MCK). Transgenic (MCK-CD36) mice had a slightly lower body weight than control …
transport of long chain fatty acids (FA). To determine the physiological role of CD36, we
examined effects of its overexpression in muscle, a tissue that depends on FA for its energy
needs and is responsible for clearing a major fraction of circulating FA. Mice with CD36
overexpression in muscle were generated using the promoter of the muscle creatine kinase
gene (MCK). Transgenic (MCK-CD36) mice had a slightly lower body weight than control …