Sodium-hydrogen exchanger regulatory factor-1 interacts with mouse urate transporter 1 to regulate renal proximal tubule uric acid transport
R Cunningham, M Brazie, S Kanumuru… - Journal of the …, 2007 - journals.lww.com
Sodium-hydrogen exchanger regulatory factor-1–deficient (NHERF-1−/−) mice demonstrate
increases in the urinary excretion of phosphate, calcium, and uric acid associated with
interstitial deposition of calcium in the papilla of the kidney. These studies examine the role
of NHERF-1 in the tubular reabsorption of uric acid and regulation of mouse urate
transporter 1 (mURAT1), a newly described transporter that is responsible for the renal
tubular reabsorption of uric acid. In primary cultures of mouse renal proximal tubule cells …
increases in the urinary excretion of phosphate, calcium, and uric acid associated with
interstitial deposition of calcium in the papilla of the kidney. These studies examine the role
of NHERF-1 in the tubular reabsorption of uric acid and regulation of mouse urate
transporter 1 (mURAT1), a newly described transporter that is responsible for the renal
tubular reabsorption of uric acid. In primary cultures of mouse renal proximal tubule cells …