Insulin, glucagon, and glucose exhibit synchronous, sustained oscillations in fasting monkeys
CJ Goodner, BC Walike, DJ Koerker, JW Ensinck… - Science, 1977 - science.org
CJ Goodner, BC Walike, DJ Koerker, JW Ensinck, AC Brown, EW Chideckel, J Palmer…
Science, 1977•science.orgIn overnight fasted rhesus monkeys, synchronous, regular oscillations occurred in the
plasma concentrations of glucose, insulin, and glucagon. The oscillations displayed a period
averaging 9 minutes. The amplitudes for insulin and glucagon were ten and five times
greater than for glucose. Insulin cycled in and glucagon out of phase with glucose. In
baboons, oscillations of glucose and insulin were smaller than in rhesus monkeys, while in
man, regular oscillations were not observed.
plasma concentrations of glucose, insulin, and glucagon. The oscillations displayed a period
averaging 9 minutes. The amplitudes for insulin and glucagon were ten and five times
greater than for glucose. Insulin cycled in and glucagon out of phase with glucose. In
baboons, oscillations of glucose and insulin were smaller than in rhesus monkeys, while in
man, regular oscillations were not observed.
In overnight fasted rhesus monkeys, synchronous, regular oscillations occurred in the plasma concentrations of glucose, insulin, and glucagon. The oscillations displayed a period averaging 9 minutes. The amplitudes for insulin and glucagon were ten and five times greater than for glucose. Insulin cycled in and glucagon out of phase with glucose. In baboons, oscillations of glucose and insulin were smaller than in rhesus monkeys, while in man, regular oscillations were not observed.
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