[HTML][HTML] Mutual transcriptional interference between RelA and androgen receptor
JJ Palvimo, P Reinikainen, T Ikonen, PJ Kallio… - Journal of Biological …, 1996 - ASBMB
Cross-modulation between androgen receptor (AR) and NF-κB/Rel proteins was studied
using various androgen-and NF-κB-regulated reporter genes under transient transfection
conditions. In COS-1 cells, elevated expression of RelA (p65) repressed AR-mediated
transactivation in a dose-dependent manner, whereas NFκB1 (p50), another major member
of the NF-κB family, did not influence transactivation. The repression of AR appeared to
involve the N-terminal region of the protein between residue 297 and the DNA-binding …
using various androgen-and NF-κB-regulated reporter genes under transient transfection
conditions. In COS-1 cells, elevated expression of RelA (p65) repressed AR-mediated
transactivation in a dose-dependent manner, whereas NFκB1 (p50), another major member
of the NF-κB family, did not influence transactivation. The repression of AR appeared to
involve the N-terminal region of the protein between residue 297 and the DNA-binding …