Gastric emptying in diabetes

MFSC Kong, IA Macdonald, RB Tattersall - Diabetic medicine, 1996 - Wiley Online Library
MFSC Kong, IA Macdonald, RB Tattersall
Diabetic medicine, 1996Wiley Online Library
Gastric emptying abnormalities are common in diabetic patients but correlate poorly with
gastrointestinal symptoms. Poor diabetic control is more likely to lead to gastrointestinal
complications of diabetes and the converse is also true. Gastric emptying may be a
previously under‐recognized contributor to variations in glycaemic control in diabetes. There
is evidence for both accelerated and delayed gastric emptying. More rapid gastric emptying
would result in higher postprandial glucose levels and, therefore, pharmacological means to …
Abstract
Gastric emptying abnormalities are common in diabetic patients but correlate poorly with gastrointestinal symptoms. Poor diabetic control is more likely to lead to gastrointestinal complications of diabetes and the converse is also true. Gastric emptying may be a previously under‐recognized contributor to variations in glycaemic control in diabetes. There is evidence for both accelerated and delayed gastric emptying. More rapid gastric emptying would result in higher postprandial glucose levels and, therefore, pharmacological means to delay the rate of gastric emptying may be a new approach to slowing postprandial nutrient absorption and improving diabetic control. Hyperglycaemia reduces the rate of gastric emptying in both Type 1 (insulin‐dependent) and Type 2 (non‐insulin‐dependent) diabetic patients. The exact mechanisms responsible for the inhibitory action of hyperglycaemia on gastric emptying are unknown. There is insufficient data on the effect of hypoglycaemia on gastric emptying but one study has reported more rapid gastric emptying.
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