[PDF][PDF] Chemokines and T lymphocytes: more than an attraction

SG Ward, K Bacon, J Westwick - Immunity, 1998 - cell.com
Immunity, 1998cell.com
(Baggiolini et al., 1997). There are now well over 40 char-The known chemokine receptors,
together with their acterized chemokines (some of which are listed in Table respective
ligands, are shown in Table 2. Chemokine 1 and Table 2) as well as a number of virally
encoded receptors are seven-transmembrane-spanning, pertuschemokine-like proteins, so
this family far outnumbers sis toxin–sensitive, G protein–coupled receptors that are other
cytokine families. Most chemokines fall into the similar to many other seven-transmembrane …
(Baggiolini et al., 1997). There are now well over 40 char-The known chemokine receptors, together with their acterized chemokines (some of which are listed in Table respective ligands, are shown in Table 2. Chemokine 1 and Table 2) as well as a number of virally encoded receptors are seven-transmembrane-spanning, pertuschemokine-like proteins, so this family far outnumbers sis toxin–sensitive, G protein–coupled receptors that are other cytokine families. Most chemokines fall into the similar to many other seven-transmembrane-spanning CXC and CC groups, since there is only one C and receptors and have a number of conserved motifs, inone CX3C chemokine known in human. The discovery cluding the DRYLAIV motif in the second intracellular of chemokine receptors also appears to be a modern loop domain (Baggiolini et al., 1997). The only exception growth industry. There are now at least 15 known cheis the Duffy antigen receptor for chemokines (DARC), mokine receptors, many of which exhibit multiple ligand which has less than 20% amino acid identity with CXC specificity, although the chemokine/ligand promiscuity and CC chemokine receptors. DARC is the only known does not usually cross CC versus CXC chemokine chemokine receptor that can bind both CC and CXC boundaries (Table 2). In addition, there are several orchemokines. In addition, DARC lacks the DRYLAIV motif, phan and virally encoded chemokine receptors, so the is not coupled to G proteins, and has not been reported number of chemokine receptors will likely increase subto elicit any detectable signal transduction events. Given stantially over the next few years. the chemotactic effects of chemokines on T lymphocytes, it was a natural assumption that T cells should express chemokine receptors, and there has been in-
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