Link protein is ubiquitously expressed in non-cartilaginous tissues where it enhances and stabilizes the interaction of proteoglycans with hyaluronic acid.
F Binette, J Cravens, B Kahoussi… - Journal of Biological …, 1994 - ASBMB
Link protein (LP) is an abundant protein of cartilage which stabilizes the interaction of
aggrecan with hyaluronic acid (HA). In this study we report that LP is also present in a large
number of embryonic non-cartilaginous tissues. We demonstrate, using RNase protection
experiments, that the coding region of the LP mRNAs isolated from these tissues is identical
to that present in cartilage. Furthermore, we show that the LP mRNAs are translated in non-
cartilaginous tissues by the identification of LP polypeptides with monoclonal antibody …
aggrecan with hyaluronic acid (HA). In this study we report that LP is also present in a large
number of embryonic non-cartilaginous tissues. We demonstrate, using RNase protection
experiments, that the coding region of the LP mRNAs isolated from these tissues is identical
to that present in cartilage. Furthermore, we show that the LP mRNAs are translated in non-
cartilaginous tissues by the identification of LP polypeptides with monoclonal antibody …