Localization of hyaluronan in mouse embryos during implantation, gastrulation and organogenesis
BA Fenderson, I Stamenkovic, A Aruffo - Differentiation, 1993 - Elsevier
Hyaluronan was localized in postimplantation mouse embryos using CD44, the principal
hyaluronan receptor. The specificity of CD44 receptor-globulin labelling was confirmed
using Streptomyces hyaluronidase, anti-chondroitin sulfate antibody, and other receptor
globulins. Our major findings are summarized as follows 1. Implantation of the blastocyst into
the uterine wall triggers a rapid loss of hyaluronan from the extracellular matrix of decidual
cells on the anti-mesometrial side of the uterus. 2. Hyaluronan appears early in development …
hyaluronan receptor. The specificity of CD44 receptor-globulin labelling was confirmed
using Streptomyces hyaluronidase, anti-chondroitin sulfate antibody, and other receptor
globulins. Our major findings are summarized as follows 1. Implantation of the blastocyst into
the uterine wall triggers a rapid loss of hyaluronan from the extracellular matrix of decidual
cells on the anti-mesometrial side of the uterus. 2. Hyaluronan appears early in development …