[HTML][HTML] Hyaluronan synthesis by mouse cumulus cells is regulated by interactions between follicle-stimulating hormone (or epidermal growth factor) and a soluble …

E Tirone, C D'Alessandris, VC Hascall… - Journal of Biological …, 1997 - ASBMB
Expansion of the cumulus cell-oocyte complex (COC) in the preovulatory mammalian follicle
requires a transient induction of hyaluronan (HA) synthesis by the cumulus cells. We studied
the interactions of known factors that regulate this process by isolating compact COCs from
mice and inducing their expansion in vitro. Maximum HA synthesis requires either follicle-
stimulating hormone (FSH) or epidermal growth factor (EGF) in combination with either a
soluble factor (s) produced by the oocyte or transforming growth factor β 1. FSH (or EGF) …