[HTML][HTML] Hyaluronan synthases

PH Weigel, VC Hascall, M Tammi - Journal of Biological Chemistry, 1997 - ASBMB
In 1934, Meyer and Palmer isolated a novel, high Mr glycosaminoglycan from the vitreous of
the eye (1). They showed that this substance contained a hexuronic acid, an amino sugar,
and no sulfoesters and proposed the name hyaluronic acid (hyaluronan, HA), 1 from the
Greek hyaloid (vitreous) and uronic acid. It took 20 years before Weissmann and Meyer (2)
finally established the precise structure of the repeating disaccharide unit of hyaluronic acid
(GlcAß (133) GlcNAcß (134)). The number of repeating disaccharides in an HA molecule …