[HTML][HTML] Arachidonic acid is preferentially metabolized by cyclooxygenase-2 to prostacyclin and prostaglandin E2

TG Brock, RW McNish, M Peters-Golden - Journal of Biological Chemistry, 1999 - ASBMB
The two cyclooxygenase isoforms, cyclooxygenase-1 and cyclooxygenase-2, both
metabolize arachidonic acid to prostaglandin H 2, which is subsequently processed by
downstream enzymes to the various prostanoids. In the present study, we asked if the two
isoforms differ in the profile of prostanoids that ultimately arise from their action on
arachidonic acid. Resident peritoneal macrophages contained only cyclooxygenase-1 and
synthesized (from either endogenous or exogenous arachidonic acid) a balance of four …