[HTML][HTML] Activation of proliferator-activated receptors α and γ induces apoptosis of human monocyte-derived macrophages
G Chinetti, S Griglio, M Antonucci, IP Torra… - Journal of Biological …, 1998 - ASBMB
Peroxisome proliferator-activated receptors (PPARs) have been implicated in metabolic
diseases, such as obesity, diabetes, and atherosclerosis, due to their activity in liver and
adipose tissue on genes involved in lipid and glucose homeostasis. Here, we show that the
PPARα and PPARγ forms are expressed in differentiated human monocyte-derived
macrophages, which participate in inflammation control and atherosclerotic plaque
formation. Whereas PPARα is already present in undifferentiated monocytes, PPARγ …
diseases, such as obesity, diabetes, and atherosclerosis, due to their activity in liver and
adipose tissue on genes involved in lipid and glucose homeostasis. Here, we show that the
PPARα and PPARγ forms are expressed in differentiated human monocyte-derived
macrophages, which participate in inflammation control and atherosclerotic plaque
formation. Whereas PPARα is already present in undifferentiated monocytes, PPARγ …