Insulin resistance is a major factor in the pathogenesis of type 2 diabetes and may be
related to alterations in fat metabolism. Fatless mice have been created using dominant-
negative protein (A-ZIP/F-1) targeted gene expression in the adipocyte and shown to
develop diabetes. To understand the mechanism responsible for the insulin resistance in
these mice, we conducted hyperinsulinemic-euglycemic clamps in awake fatless and wild
type littermates before the development of diabetes and examined insulin action and …