Lesional expression of interferon-γ in atopic eczema
M Grewe, K Gyufko, E Schöpf, J Krutmann - The Lancet, 1994 - Elsevier
M Grewe, K Gyufko, E Schöpf, J Krutmann
The Lancet, 1994•ElsevierAtopic eczema is thought to be caused by skin-infiltrating CD4 T cells of the Th 1-like and/or
Th 2-like subtype. We assessed expression of the Th 1-like cytokine, interferon-γ, and the Th
2-like cytokine, interleukin-4, in lesional atopic skin. Compared with that in normal skin,
interferon-γ and interleukin-4 mRNA expression were increased in eczematous skin lesions
in 13 and 4 of 15 patients, respectively. After successful therapy of atopic dermatitis, the
increased interferon-γ mRNA expression but not the increased interleukin-4 mRNA …
Th 2-like subtype. We assessed expression of the Th 1-like cytokine, interferon-γ, and the Th
2-like cytokine, interleukin-4, in lesional atopic skin. Compared with that in normal skin,
interferon-γ and interleukin-4 mRNA expression were increased in eczematous skin lesions
in 13 and 4 of 15 patients, respectively. After successful therapy of atopic dermatitis, the
increased interferon-γ mRNA expression but not the increased interleukin-4 mRNA …
Abstract
Atopic eczema is thought to be caused by skin-infiltrating CD4 T cells of the Th1-like and/or Th2-like subtype. We assessed expression of the Th1-like cytokine, interferon-γ, and the Th2-like cytokine, interleukin-4, in lesional atopic skin. Compared with that in normal skin, interferon-γ and interleukin-4 mRNA expression were increased in eczematous skin lesions in 13 and 4 of 15 patients, respectively. After successful therapy of atopic dermatitis, the increased interferon-γ mRNA expression but not the increased interleukin-4 mRNA expression was significantly downregulated. These data indicate that in-situ expression of interferon-γ is linked to the clinical course of atopic dermatitis.
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